Article
The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan.
Atherosclerosis - 1 Dec 1998
Ko Y L, Ko Y S, Wang S M, Hsu L A, Chang C J, Chu P H, Cheng N J, Chen W J, Chiang C W, Lee Y S
Abstract excerpt
Paraoxonase (PON1) is a high density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, and thus, might protect lipoproteins from oxidation. A common polymorphism due to an amino acid substitution (Gln-Arg) at codon 191 is considered to be a major determinant of variation in serum PON1 activity. Recent studies have suggested that the PON1-191 polymorphism is an independent risk factor for...
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