Article
The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan.
Atherosclerosis - 1 Dec 1998
Ko Y L, Ko Y S, Wang S M, Hsu L A, Chang C J, Chu P H, Cheng N J, Chen W J, Chiang C W, Lee Y S
Abstract excerpt
Paraoxonase (PON1) is a high density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, and thus, might protect lipoproteins from oxidation. A common polymorphism due to an amino acid substitution (Gln-Arg) at codon 191 is considered to be a major determinant of variation in se...
Topics
- Alleles
- Amino Acid Substitution
- Aryldialkylphosphatase
- China
- Coronary Disease
- Esterases
- Female
- Genotype
- Humans
- Logistic Models
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- Taiwan