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Article

A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Rivera-Molina Félix E, Novick Peter J

Abstract excerpt

Membrane traffic along the endocytic and exocytic pathways relies on the appropriate localization and activation of a series of different Rab GTPases. Rabs are activated by specific guanine nucleotide exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). GEF cascades, in which one Rab in its GTP-bound form recruits the GEF that activates the next Rab along the pathway, can account for the...

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Identifiers

PMID: 19666511
DOI: 10.1073/pnas.0906536106
PMCID: PMC2732877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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