Article
Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 1998
Van Schooten F J, Hirvonen A, Maas L M, De Mol B A, Kleinjans J C, Bell D A, Durrer J D
Abstract excerpt
Cancer and cardiovascular diseases share risk factors such as smoking, and the onset of both diseases have been suggested to have a common mechanistic basis. The binding of carcinogens to DNA (carcinogen-DNA adducts), genetic polymorphisms in carcinogen-detoxifying enzymes glutathione S-transfera...
Topics
- Adult
- Aged
- Biomarkers
- Calcitriol
- Coronary Angiography
- Coronary Disease
- DNA Adducts
- Female
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Heart Atria
- Heart Diseases
- Humans
- Hypercholesterolemia