Article
Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 1998
Van Schooten F J, Hirvonen A, Maas L M, De Mol B A, Kleinjans J C, Bell D A, Durrer J D
Abstract excerpt
Cancer and cardiovascular diseases share risk factors such as smoking, and the onset of both diseases have been suggested to have a common mechanistic basis. The binding of carcinogens to DNA (carcinogen-DNA adducts), genetic polymorphisms in carcinogen-detoxifying enzymes glutathione S-transferases (GSTs), and genetic polymorphisms in the vitamin D receptor (VDR) are among the candidates for modifiers of cancer...
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