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Article

Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2003

Masetti Serena, Botto Nicoletta, Manfredi Samantha, Colombo Maria Giovanna, Rizza Antonio, Vassalle Cristina, Clerico Aldo, Biagini Andrea, Andreassi Maria Grazia

Abstract excerpt

Cardiovascular diseases and cancer are the main causes of death in developed countries. Mortality trends for these diseases suggest that they share common pathogenetic mechanisms. Glutathione S-transferase (GST) is a family of enzymes that detoxify reactive electrophiles, particularly present in tobacco smoke. Glutathione S-transferase null M1 and T1 (GSTM1 and GSTT1) genotypes have often been associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12811412
DOI: 10.1007/s00109-003-0448-5

Genes

CAD
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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