Article
A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension.
Thrombosis and haemostasis - 1 Sept 1998
Yoshida H, Imaizumi T, Fujimoto K, Itaya H, Hiramoto M, Yoshimizu N, Fukushi K, Satoh K
Abstract excerpt
Platelet-activating factor (PAF) acetylhydrolase is an enzyme that inactivates PAF. Deficiency of this enzyme is caused by a missense mutation in the gene. We previously found a higher prevalence of this mutation in patients with ischemic stroke. This fact suggests that the mutation might enhance...
Topics
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Aged
- Cerebral Hemorrhage
- Female
- Genetic Markers
- Humans
- Hypertension
- Male
- Middle Aged
- Mutation
- Phospholipases A
- Risk Factors