Article
Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese.
Annals of surgery - 1 Feb 2002
Unno Naoki, Nakamura Toshio, Mitsuoka Hiroshi, Uchiyama Takashi, Yamamoto Naoto, Saito Takaaki, Sugatani Junko, Miwa Masao, Nakamura Satoshi
Abstract excerpt
OBJECTIVE: To investigate a possible association with plasma platelet activating factor acetylhydrolase (PAF-AH) gene mutation with the risk of abdominal aortic aneurysm (AAA). SUMMARY BACKGROUND DATA: Plasma platelet activating factor acetylhydrolase is known to catalyze platelet activating factor (PAF), thereby inactivating its inflammatory function. Deficiency of this enzyme is caused by a missense mutation...
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