Article
A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke.
Stroke - 1 Dec 1997
Hiramoto M, Yoshida H, Imaizumi T, Yoshimizu N, Satoh K
Abstract excerpt
BACKGROUND AND PURPOSE: Platelet-activating factor (PAF) is a phospholipid with multiple actions that include thrombosis and inflammation. It is inactivated by a plasma enzyme, PAF acetylhydrolase. Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (Val279-->Phe). We have studied a possible association of this mutation with the risk of stroke. SUBJECTS AND METHODS: We studied 120...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.