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Article

Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.

Stroke - 1 Nov 2005

Ranade Koustubh, Kirchgessner Todd G, Iakoubova Olga A, Devlin James J, DelMonte Terrye, Vishnupad Priya, Hui Lester, Tsuchihashi Zenta, Sacks Frank M, Sabatine Marc S, Braunwald Eugene, White Thomas J, Shaw Peter M, Dracopoli Nicholas C

Abstract excerpt

BACKGROUND AND PURPOSE: The paraoxonases are involved in protecting low-density lipoprotein (LDL) from lipid oxidation. Paraoxonase 1 (PON1) was implicated in susceptibility to coronary artery disease and stroke in previous studies. We evaluated, in a comprehensive way, all 3 paraoxonase genes for association with stroke observed in the Cholesterol and Recurrent Events (CARE) trial. METHODS: Over 2500 subjects...

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Source

Identifiers

PMID: 16239632
DOI: 10.1161/01.STR.0000185703.88944.7d

Genes

PON1
PON2
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.PMID 16239632Read ↗

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