Article
Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women.
Nutrition research (New York, N.Y.) - 1 Apr 2011
Nagai Narumi, Sakane Naoki, Kotani Kazuhiko, Hamada Taku, Tsuzaki Kokoro, Moritani Toshio
Abstract excerpt
Uncoupling protein 1 (UCP1) plays an important role in thermogenesis in brown adipose tissue. Previously, we reported an association between -3826 A/G single-nucleotide polymorphism (SNP) in the promoter of UCP1 gene and lower thermogenesis in young women, suggesting this SNP has an adverse effect on the regulation of energy balance. Based on the hypothesis that this SNP (G allele) may have resistance against...
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