Article
Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6.
European journal of clinical pharmacology - 1 Jul 1998
Hadidi H, Irshaid Y, Vågbø C B, Brunsvik A, Cholerton S, Zahlsen K, Idle J R
Abstract excerpt
OBJECTIVE: To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predomin...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Coumarins
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 Enzyme System
- Female
- Gas Chromatography-Mass Spectrometry
- Genetic Variation
- Humans
- Hydroxylation
- Jordan
- Male
- Mixed Function Oxygenases
- Phenylacetates
- Polymorphism, Genetic
- Umbelliferones