Article
Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.
Behavioural brain research - 1 Sept 1998
Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F
Abstract excerpt
Expression of alpha-secretion mutant APP/RK in mouse brain results in a progressive disorganization of the central nervous system, exemplified by behavioral deficits, premature death and neuropathology. Here we report on the progressive nature of this CNS disorder as indicated by the age dependency of the neophobic reaction in the open-field test. The earlier reported NMDA hypo-sensitivity in the transgenic...
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