Efficient induction of cytotoxic CD8+ T cells against exogenous proteins: establishment and characterization of a T cell line specific for the membrane protein ActA of Listeria monocytogenes.

doi:10.1002/(SICI)1521-4141(199809)28:09<2630::AID-IMMU2630>3.0.CO;2-Z

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Article

Efficient induction of cytotoxic CD8+ T cells against exogenous proteins: establishment and characterization of a T cell line specific for the membrane protein ActA of Listeria monocytogenes.

European journal of immunology - 1 Sept 1998

Bruder D, Darji A, Gakamsky D M, Chakraborty T, Pecht I, Wehland J, Weiss S

Abstract excerpt

The property of listeriolysin (LLO) to introduce soluble passenger proteins into the cytosol of antigen-presenting cells allows the induction of CD8+ cytotoxic T cells against such antigens. To overcome the potential problem of presentation of the immunodominant epitope LL091-99 by H-2Kd, a varia...

Topics

Animals
Antigen Presentation
Antigens, Bacterial
Bacterial Proteins
Bacterial Toxins
CD8-Positive T-Lymphocytes
Cell Line
Cytotoxicity, Immunologic
Heat-Shock Proteins
Hemolysin Proteins
Listeria monocytogenes
Membrane Proteins
Mice

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Mice, Inbred BALB C

Mice, Inbred C57BL

Mutation

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Identifiers

PMID: 9754551
DOI: 10.1002/(SICI)1521-4141(199809)28:09<2630::AID-IMMU2630>3.0.CO;2-Z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9754551-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.