Article
Function of steroidogenic factor 1 (SF1) ligand-binding domain in gene activation and interaction with AP1.
Biochemical and biophysical research communications - 18 Sept 1998
Li L A, Lala D, Chung B C
Abstract excerpt
The nuclear receptor SF1 is an essential mediator in ventromedial hypothalamus-pituitary-gonadal development. As with other nuclear receptors, SF1 possesses a DNA-binding domain composed of two zinc fingers and a ligand-binding domain containing a ligand-dependent activation sequence termed AF2. To dissect the domain function of SF1, we examined various SF1 mutants in mouse adrenocortical Y1 cells and human...
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