Article
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2008
Roizen Jeffrey D, Asada Minoru, Tong Min, Tai Hsin-Hsiung, Muglia Louis J
Abstract excerpt
Parturition is a complex mammalian physiological process whose fundamental determinants have remained elusive. The increasing incidence of human preterm birth, a leading cause of infant mortality, highlights the importance of further understanding mechanisms regulating the timing of birth. Parturition is initiated in most nonprimate mammals, including mice, through a decrease in circulating progesterone caused by...
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