A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors.

doi:10.1210/endo.139.10.6260

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Article

A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors.

Endocrinology - 1 Oct 1998

Flanagan C A, Fromme B J, Davidson J S, Millar R P

Abstract excerpt

Cloning of GnRH receptors from several animal species has made it possible to investigate receptor function using site-directed mutagenesis. However, many mutant GnRH receptors exhibit decreased ligand binding, which makes analysis of their ligand binding characteristics technically difficult. To...

Topics

Animals
Binding, Competitive
COS Cells
Gonadotropin-Releasing Hormone
Iodine Radioisotopes
Isotope Labeling
Mice
Mutation
Receptors, LHRH

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