Article
Influence of a species-specific extracellular amino acid on expression and function of the human gonadotropin-releasing hormone receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1999
Arora K K, Chung H O, Catt K J
Abstract excerpt
The mammalian GnRH receptor is an atypical G protein-coupled receptor which lacks the C-terminal cytoplasmic tail that is present in all other seven-transmembrane domain receptors. The mouse and rat GnRH receptors contain 327 amino acids, whereas human, sheep, and bovine receptors have an additional residue in the second extracellular loop at position 191. Another notable species difference is that human...
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