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Article

Mitochondria in the etiology and pathogenesis of parkinson's disease

1 Sept 1998

Abstract excerpt

Mitochondria play a critical role in cellular energy metabolism. The identification of a respiratory chain defect in Parkinson's disease (PD) provides not only a direct link with toxin models of parkinsonism but also insight into the mechanisms involved in etiology and pathogenesis. The presence of the complex I deficiency in PD substantia nigra and platelets suggests the involvement of a systemic cause. Genomic...

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PMID: 9749579
DOI: 10.1002/ana.410440714

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