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Article

Gene Therapeutic Approaches for the Treatment of Mitochondrial Dysfunction in Parkinson’s Disease

22 Nov 2021

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction has been identified as a pathophysiological hallmark of disease onset and progression in patients with Parkinsonian disorders. Besides the overall emergence of gene therapies in treating these patients, this highly relevant molecular concept has not yet been defined as a target for gene therapeutic approaches. METHODS: This narrative review will discuss the experimental...

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PMID: 34828446
DOI: 10.3390/genes12111840

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