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Article

Evidence for mitochondrial dysfunction in Parkinson's disease—a critical appraisal

1 Jan 1994

Abstract excerpt

There is now considerable evidence to support a defect of the mitochondrial respiratory chain, and complex I in particular, in Parkinson's Disease (PD). However, the site specificity of the defect within the chain, its anatomical selectivity within the brain, and its presence in other tissues still remain controversial. Much of the present confusion surrounding the mitochondrial defect can be dispelled by careful...

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PMID: 8196673
DOI: 10.1002/mds.870090202

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