Article
The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea.
Mutation research - 21 Mar 1997
Favor J, Neuhäuser-Klaus A, Ehling U H, Wulff A, van Zeeland A A
Abstract excerpt
Our earlier analyses have suggested an apparent threshold dose-response for ethylnitrosourea-induced specific-locus mutations in treated spermatogonia of the mouse to be due to a saturable repair process. In the current study a series of fractionated-treatment experiments was carried out in which...
Topics
- Animals
- Ethylnitrosourea
- Female
- Genetic Markers
- Infertility, Male
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred Strains
- Mutagenicity Tests
- Mutagens
- Mutation
- Phenotype
- Spermatogenesis
- Spermatogonia
- Time Factors