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Article

Isolation and characterization of high-osmolarity-sensitive mutants of fission yeast.

Journal of bacteriology - 1 Oct 1998

Aiba H, Kawaura R, Yamamoto E, Yamada H, Takegawa K, Mizuno T

Abstract excerpt

For the fission yeast Schizosaccharomyces pombe, adaptation to high-osmolarity medium is mediated by a mitogen-activated protein (MAP) kinase cascade, involving the Wis1 MAP kinase kinase and the Sty1 MAP kinase. The MAP kinase pathway transduces an osmotic signal and accordingly regulates the expression of the downstream target gene (gpd1(+)) that encodes NADH-dependent glycerol-3-phosphate dehydrogenase, in...

Topics

Culture Media
GTP-Binding Proteins
Genetic Complementation Test
Glycerol
Monomeric GTP-Binding Proteins
Mutation
Osmolar Concentration
Osmotic Pressure
Phylogeny
Potassium Chloride
RNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Schizosaccharomyces

Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 9748434
DOI: 10.1128/JB.180.19.5038-5043.1998
PMCID: PMC107537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9748434-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Isolation and characterization of high-osmolarity-sensitive mutants of fission yeast.PMID 9748434Read ↗

Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth.Semantic proximity Read ↗

Identification and characterization of a novel gene, hos3+, the function of which is necessary for growth under high osmotic stress in fission yeast.Semantic proximity Read ↗

A gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD+) complements an osmosensitive mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

Hyperthermotolerant fission yeast mutations, sow1 and sow2, suppress the cell cycle defect and stress sensitivity of MAP kinase kinase wis1Delta.Semantic proximity Read ↗

Reshaping the stress-growth balance in Saccharomyces cerevisiae through heavy ion beam irradiation and adaptive evolution to achieve high-efficiency osmotolerance: Phenotypic and mechanistic perspectives.Semantic proximity Read ↗

The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.Semantic proximity Read ↗

An integrated view on a eukaryotic osmoregulation system.Semantic proximity Read ↗

Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress.Semantic proximity Read ↗

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.Semantic proximity Read ↗

Sphingolipids regulate the yeast high-osmolarity glycerol response pathway.Semantic proximity Read ↗

Cdc37p is involved in osmoadaptation and controls high osmolarity-induced cross-talk via the MAP kinase Kss1p.Semantic proximity Read ↗

The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.Semantic proximity Read ↗

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