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Article

Trigger factor and DnaK cooperate in folding of newly synthesized proteins.

Nature - 12 Aug 1999

Deuerling E, Schulze-Specking A, Tomoyasu T, Mogk A, Bukau B

Abstract excerpt

The role of molecular chaperones in assisting the folding of newly synthesized proteins in the cytosol is poorly understood. In Escherichia coli, GroEL assists folding of only a minority of proteins and the Hsp70 homologue DnaK is not essential for protein folding or cell viability at intermediate growth temperatures. The major protein associated with nascent polypeptides is ribosome-bound trigger factor, which...

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Identifiers

PMID: 10458167
DOI: 10.1038/23301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Trigger factor and DnaK cooperate in folding of newly synthesized proteins.PMID 10458167Read ↗

Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains.Semantic proximity Read ↗

Structure and function of the molecular chaperone Trigger Factor.Semantic proximity Read ↗

Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.Semantic proximity Read ↗

Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.Semantic proximity Read ↗

Evaluation of similarities in the cis/trans isomerase function of trigger factor and DnaK.Semantic proximity Read ↗

DnaK chaperone machine and trigger factor are only partially required for normal growth of Bacillus subtilis.Semantic proximity Read ↗

The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity.Semantic proximity Read ↗

Trigger factor lacking the PPIase domain can enhance the folding of eukaryotic multi-domain proteins in Escherichia coli.Semantic proximity Read ↗

L23 protein functions as a chaperone docking site on the ribosome.Semantic proximity Read ↗

Successive action of Escherichia coli chaperones in vivo.Semantic proximity Read ↗

PPIase domain of trigger factor acts as auxiliary chaperone site to assist the folding of protein substrates bound to the crevice of trigger factor.Semantic proximity Read ↗

DnaK-dependent ribosome biogenesis in Escherichia coli: competition for dominance between the alleles dnaK756 and dnaK+.Semantic proximity Read ↗

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