Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.

doi:10.1101/gad.12.18.2887

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Article

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.

Genes & development - 15 Sept 1998

Bardwell L, Cook J G, Voora D, Baggott D M, Martinez A R, Thorner J

Abstract excerpt

The mitogen-activated protein kinase (MAPK) Kss1 has a dual role in regulating filamentous (invasive) growth of the yeast Saccharomyces cerevisiae. The stimulatory function of Kss1 requires both its catalytic activity and its activation by the MAPK/ERK kinase (MEK) Ste7; in contrast, the inhibitory function of Kss1 requires neither. This study examines the mechanism by which Kss1 inhibits invasive growth, and how...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
Calcium-Calmodulin-Dependent Protein Kinases
DNA, Recombinant
Enzyme Activation
Fungal Proteins
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Fungal
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Models, Biological

Molecular Sequence Data

Mutation

Phosphorylation

Protein Binding

Protein Kinases

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 9744865
DOI: 10.1101/gad.12.18.2887
PMCID: PMC317171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9744865-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.PMID 9744865Read ↗

Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.Semantic proximity Read ↗

Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.Semantic proximity Read ↗

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.Semantic proximity Read ↗

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.Semantic proximity Read ↗

Constitutive activation of the Saccharomyces cerevisiae transcriptional regulator Ste12p by mutations at the amino-terminus.Semantic proximity Read ↗

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.Semantic proximity Read ↗

The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components.Semantic proximity Read ↗

Hsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway.Semantic proximity Read ↗

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Semantic proximity Read ↗

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.Semantic proximity Read ↗

Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50.Semantic proximity Read ↗

Nuclear relocation of Kss1 contributes to the specificity of the mating response.Semantic proximity Read ↗

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