Article
High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo.
The Journal of experimental medicine - 21 Sept 1998
Ogg G S, Rod Dunbar P, Romero P, Chen J L, Cerundolo V
Abstract excerpt
Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted c...
Topics
- Alleles
- Autoimmune Diseases
- Cell Line
- Cell Movement
- Cytotoxicity Tests, Immunologic
- HLA-A Antigens
- Humans
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Melanocytes
- Melanoma
- Peptides
- Skin
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured
- Vitiligo