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Article

High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo.

The Journal of experimental medicine - 21 Sept 1998

Ogg G S, Rod Dunbar P, Romero P, Chen J L, Cerundolo V

Abstract excerpt

Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals with vitiligo....

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Identifiers

PMID: 9743539
DOI: 10.1084/jem.188.6.1203
PMCID: PMC2212532

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