Article
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.
The Journal of experimental medicine - 6 Sept 1999
Pittet M J, Valmori D, Dunbar P R, Speiser D E, Liénard D, Lejeune F, Fleischhauer K, Cerundolo V, Cerottini J C, Romero P
Abstract excerpt
Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specific cytolytic T lymphocytes (CTLs). In this paper, we enumerated and characterized ex vivo Melan-A-specific cells in peripheral blood samples from both melanoma...
Topics
- Adult
- Aged
- Antigens, Neoplasm
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- HLA-A2 Antigen
- Humans
- Immunologic Memory
- Interferon-gamma
- Lymphocyte Count
- MART-1 Antigen
- Melanoma
- Middle Aged