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Article

High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.

The Journal of experimental medicine - 6 Sept 1999

Pittet M J, Valmori D, Dunbar P R, Speiser D E, Liénard D, Lejeune F, Fleischhauer K, Cerundolo V, Cerottini J C, Romero P

Abstract excerpt

Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specific cytolytic T lymphocytes (CTLs). In this paper, we enumerated and characterized ex vivo Melan-A-specific cells in peripheral blood samples from both melanoma...

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Source

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Identifiers

PMID: 10477554
DOI: 10.1084/jem.190.5.705
PMCID: PMC2195613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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