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Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens.

Investigative ophthalmology & visual science - 1 Jun 2006

Sugita Sunao, Takase Hiroshi, Taguchi Chikako, Imai Yasuhisa, Kamoi Koju, Kawaguchi Tatsushi, Sugamoto Yoshiharu, Futagami Yuri, Itoh Kyogo, Mochizuki Manabu

Abstract excerpt

PURPOSE: To determine whether patients with Vogt-Koyanagi-Harada (VKH) disease have immune responses specific to the melanocyte antigens tyrosinase and gp100. METHODS: T-cell clones (TCCs) were established from cells infiltrating the aqueous humor and from peripheral blood mononuclear cells (PBMCs) of patients with VKH. The target cells were LDR4-transfected cells (HLA-DRB1*0405). The TCCs were cocultured with...

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PMID: 16723469
DOI: 10.1167/iovs.05-1547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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