A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

doi:10.1073/pnas.92.17.7976

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Article

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1995

Coulie P G, Lehmann F, Lethé B, Herman J, Lurquin C, Andrawiss M, Boon T

Abstract excerpt

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor...

Topics

Alleles
Amino Acid Sequence
Antigens, Neoplasm
Base Sequence
Binding, Competitive
Cell Line
Cloning, Molecular
Cytotoxicity, Immunologic
Exons
Humans
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Melanoma

Molecular Sequence Data

Mutagenesis

Neoplasm Proteins

Point Mutation

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7644523
DOI: 10.1073/pnas.92.17.7976
PMCID: PMC41269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7644523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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