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Article

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1995

Coulie P G, Lehmann F, Lethé B, Herman J, Lurquin C, Andrawiss M, Boon T

Abstract excerpt

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor...

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Identifiers

PMID: 7644523
DOI: 10.1073/pnas.92.17.7976
PMCID: PMC41269

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