Article
Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBPbeta: both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 1998
Mietus-Snyder M, Glass C K, Pitas R E
Abstract excerpt
Reactive oxygen species generated by treatment of smooth muscle cells (SMCs) with either phorbol 12-myristate 13-acetate or with the combination of H2O2 and vanadate strongly induce expression of the class A scavenger receptor (SR-A) gene. In the current studies, cis-acting elements in the proxim...
Topics
- Animals
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- DNA
- DNA-Binding Proteins
- Gene Expression
- Humans
- Hydrogen Peroxide
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- Macrophages
- Membrane Proteins
- Mitogen-Activated Protein Kinase Kinases