Article
Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells.
Journal of vascular research - 1 Jan 2006
Gidlof Andreas C, Ocaya Pauline, Olofsson Peder S, Torma Hans, Sirsjo Allan
Abstract excerpt
Vascular disease is multifactorial and smooth muscle cells (SMCs) play a key role. Retinoids have been shown to influence many disease-promoting processes including proliferation and differentiation in the vessel wall. Phenotypic heterogeneity of vascular SMCs is a well-known phenomenon and phenotypic modulation of SMCs precedes intimal hyperplasia. The SMCs that constitute the intimal hyperplasia demonstrate a...
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