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Article

A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses.

The European journal of neuroscience - 1 Dec 2006

Kodama Takashi, Itsukaichi-Nishida Yuko, Fukazawa Yugo, Wakamori Minoru, Miyata Mariko, Molnar Elek, Mori Yasuo, Shigemoto Ryuichi, Imoto Keiji

Abstract excerpt

The rocker mice are hereditary ataxic mutants that carry a point mutation in the gene encoding the CaV2.1 (P/Q-type) Ca2+ channel alpha1 subunit, and show the mildest symptoms among the reported CaV2.1 mutant mice. We studied the basic characteristics of the rocker mutant Ca2+ channel and their impacts on excitatory synaptic transmission in cerebellar Purkinje cells (PCs). In acutely dissociated PC somas, the...

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Identifiers

PMID: 17156361
DOI: 10.1111/j.1460-9568.2006.05191.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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