Article
Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 1998
Schunkert H, Hense H W, Döring A, Riegger G A, Siffert W
Abstract excerpt
Gi proteins mediate the intracellular effects of many vasoactive and proliferative stimuli. Recently such signaling was found to be enhanced in cultured cells of some hypertensive subjects. A polymorphism at position 825 (C-->T) of the G protein beta3 subunit gene (GNB3) was strictly related to t...
Topics
- Aged
- Aldosterone
- Analysis of Variance
- Anthropometry
- Antihypertensive Agents
- Blood Pressure
- Cohort Studies
- Enzyme Precursors
- Female
- GTP-Binding Proteins
- Genotype
- Health Surveys
- Humans
- Hypertension
- Male
- Middle Aged
- Polymorphism, Genetic
- Radioimmunoassay