Article
Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.
Mutation research - 10 Jan 2011
Kaliyaperumal Saravanan, Patrick Steve M, Williams Kandace J
Abstract excerpt
DNA mismatch repair (MMR) maintains genomic integrity by correction of mispaired bases and insertion-deletion loops. The MMR pathway can also trigger a DNA damage response upon binding of MutSα to specific DNA lesions such as O(6)methylguanine (O(6)meG). Limited information is available regarding cellular regulation of these two different pathways. Within this report, we demonstrate that phosphorylated hMSH6...
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