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VP1 molecular evolution of type 2 immunodeficiency-related vaccine-derived polioviruses (iVDPV2) in a patient with primary immunodeficiency disease (PID).

Virus genes - 1 Apr 2026

Nejati Ahmad, Khodakhah Farshad, Soheili Parastoo, Yousefi Maryam, Mollaei-Kandelous Yaghoob, Keyvanlou Maryam, Razaghi Mohammad, Yaghoubzadeh Delaram, Zahraei Seyed Mohsen, Mahmoudi Sussan, Shahmahmoodi Shohreh

Abstract excerpt

Vaccine-derived polioviruses (VDPVs) arising after use of oral poliovirus vaccine (OPV) are an important impediment to the polio endgame, particularly in settings with low population immunity or prolonged infections in immunodeficient individuals.If immunocompromised individuals such as patients with primary immunodeficiency (PID) receive OPV, the live attenuated vaccine virus will replicate in their intestinal...

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PMID: 41629698
DOI: 10.1007/s11262-026-02214-1

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