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Article

Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron.

Journal of molecular biology - 25 Sept 1998

Schmidt U, Maue I, Lehmann K, Belcher S M, Stahl U, Perlman P S

Abstract excerpt

Previous studies show that some yeast strains carrying point mutations of domain 5 that block splicing of a mitochondrial group II intron yield spontaneous revertants in which splicing is partially restored by dominant mutations of nuclear genes. Here we cloned and sequenced the suppressor allele of one such gene, and found it to be a missense mutation of the MRS2 gene (MRS2-L232F). The MRS2 gene was first...

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Source

Identifiers

PMID: 9737920
DOI: 10.1006/jmbi.1998.2021

Genes

MRS2

Variants

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Related research

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Research trail→

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Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron.PMID 9737920Read ↗

The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo.Semantic proximity Read ↗

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MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.Semantic proximity Read ↗

Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron.Semantic proximity Read ↗

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