Article
Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron.
Journal of molecular biology - 25 Sept 1998
Schmidt U, Maue I, Lehmann K, Belcher S M, Stahl U, Perlman P S
Abstract excerpt
Previous studies show that some yeast strains carrying point mutations of domain 5 that block splicing of a mitochondrial group II intron yield spontaneous revertants in which splicing is partially restored by dominant mutations of nuclear genes. Here we cloned and sequenced the suppressor allele...
Topics
- Alleles
- Amino Acid Sequence
- DNA, Fungal
- DNA, Mitochondrial
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Suppressor
- Introns
- Ion Channels
- Mitochondrial Proteins
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins