Article
Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo.
Genes & development - 1 Sept 2001
Gregan J, Kolisek M, Schweyen R J
Abstract excerpt
The product of the nuclear MRS2 gene, Mrs2p, is the only candidate splicing factor essential for all group II introns in mitochondria of the yeast Saccharomyces cerevisiae. It has been shown to be an integral protein of the inner mitochondrial membrane, structurally and functionally related to the bacterial CorA Mg(2+) transporter. Here we show that mutant alleles of the MRS2 gene as well as overexpression of...
Topics
- Alleles
- Dose-Response Relationship, Drug
- Exons
- Genetic Vectors
- Genotype
- Introns
- Magnesium
- Mitochondria
- Models, Genetic
- Mutation
- Plasmids
- RNA Splicing
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Saccharomyces cerevisiae
- Sensitivity and Specificity
- Suppression, Genetic
- Time Factors