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Article

Conditional lineage ablation to model human diseases

15 Sept 1998

Abstract excerpt

Cell loss contributes to the pathogenesis of many inherited and acquired human diseases. We have developed a system to conditionally ablate cells of any lineage and developmental stage in the mouse by regulated expression of the diphtheria toxin A (DTA) gene by using tetracycline-responsive promoters. As an example of this approach, we targeted expression of DTA to the hearts of adult mice to model structural...

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PMID: 9736743
DOI: 10.1073/pnas.95.19.11371

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