Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.

Abstract excerpt

Developmental defects and disruption of molecular pathways of the cardiac conduction system (CCS) can cause life-threatening cardiac arrhythmias. Despite decades of effort, knowledge about the development and molecular control of the CCS remains primitive. Mouse genetics, complementary to other approaches such as human genetics, has become a key tool for exploring the developmental processes of various organs and...

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