Article
Allelic association under map error and recombinational heterogeneity: a tale of two sites.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998
Lonjou C, Collins A, Ajioka R S, Jorde L B, Kushner J P, Morton N E
Abstract excerpt
Recombination acts on the genetic map, not on the physical map. On the other hand, the physical map is usually more accurate. Choice of the genetic or physical map for positional cloning by allelic association depends on the goodness of fit of data to each map under an established model. Huntington disease illustrates the usual case in which the greater reliability of physical data outweighs recombinational...
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