Article
Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2007
Bouhlal Hicham, Chomont Nicolas, Réquena Mary, Nasreddine Nadine, Saidi Héla, Legoff Jérôme, Kazatchkine Michel D, Bélec Laurent, Hocini Hakim
Abstract excerpt
In the present study, we demonstrated that opsonization of primary HIV-1 with human complement enhances infection of immature monocyte-derived dendritic cells (iDC) and transmission in trans of HIV to autologous CD4(+) T lymphocytes. Infection of iDC by opsonized primary R5- and X4-tropic HIV was increased 3- to 5-fold as compared with infection by the corresponding unopsonized HIV. Enhancement of infection was...
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