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Article

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

19 Jun 2019

Abstract excerpt

Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. Chimeric mAb 2C7 (human immunoglobulin G1 [IgG1]) with an E430G Fc modification that enhances Fc:Fc interactions and hexamerization following surface-target binding...

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PMID: 31216278
DOI: 10.1371/journal.pbio.3000323

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