Article
Collagen synthesis by cultured rabbit aortic smooth-muscle cells. Alteration with phenotype.
The Biochemical journal - 15 Jan 1990
Ang A H, Tachas G, Campbell J H, Bateman J F, Campbell G R
Abstract excerpt
Enzymically isolated rabbit aortic smooth-muscle cells (SMC) in the first few days of primary culture express a 'contractile phenotype', but with time these cells modulate to a 'synthetic phenotype'. Synthetic-state SMC are able to proliferate, and, provided that they undergo fewer than 5 cumulative population doublings, return to the contractile phenotype after reaching confluency [Campbell, Kocher, Skalli,...
Topics
- Animals
- Aorta
- Aorta, Abdominal
- Aorta, Thoracic
- Cell Division
- Cells, Cultured
- Collagen
- Kinetics
- Muscle, Smooth, Vascular
- Nucleic Acid Hybridization
- Phenotype
- Poly A