Article
Phenotype dictates the growth response of vascular smooth muscle cells to pulse pressure in vitro.
Experimental cell research - 10 Jul 1999
Cappadona C, Redmond E M, Theodorakis N G, McKillop I H, Hendrickson R, Chhabra A, Sitzmann J V, Cahill P A
Abstract excerpt
The objective of this study was to determine the effect of phenotype on pulse pressure-induced signaling and growth of vascular smooth muscle cells in vitro. Using a perfused transcapillary culture system, cells were exposed to increases in pulsatile flow and hence pulse pressure and maintained for 72 h before cells were harvested. Cell proliferation was determined by cell number, DNA synthesis, and proliferating...
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