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Article

Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Oct 2006

Hillion Joëlle A, Li YiXin, Maric Dragan, Takanohashi Asako, Klimanis Dace, Barker Jeffrey L, Hallenbeck John M

Abstract excerpt

The serine-threonine protein kinase Akt has been identified as an important mediator of cell survival able to counteract apoptotic stimuli. However, hibernation, a model of natural tolerance to cerebral ischemia, is associated with downregulation of Akt. We previously established a model of ischemic tolerance in a PC12 cell line and using this model we now addressed the question whether ischemic tolerance also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16511503
DOI: 10.1038/sj.jcbfm.9600286
PMCID: PMC1855183

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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