Article
On the stochastic regulation of interleukin-2 transcription.
Seminars in immunology - 1 Oct 1999
Holländer G A
Abstract excerpt
Interleukin-2 (IL-2) is a growth and differentiation factor critical for clonal T cell expansion and function. Produced exclusively in T cells, IL-2 transcription and synthesis occurs only after appropriate cellular activation via the clonotypic antigen-receptor and co-stimulatory molecules. IL-2 gene expression is initiated by the cooperative binding of different transcription factors and is predominantly...
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