Article
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Merkel M, Kako Y, Radner H, Cho I S, Ramasamy R, Brunzell J D, Goldberg I J, Breslow J L
Abstract excerpt
Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis. In vitro studies have shown that LPL also can enhance lipoprotein uptake into cells via pathways that are independent of catalytic activity but require LPL as a molecular bridge between lipoproteins and proteoglycan...
Topics
- Animals
- Cells, Cultured
- Humans
- Lipoprotein Lipase
- Lipoproteins, VLDL
- Mice
- Mice, Transgenic
- Muscle, Skeletal
- Mutation