Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion.

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Article

Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion.

The Journal of biological chemistry - 15 Oct 1990

Davis R C, Ben-Zeev O, Martin D, Doolittle M H

Abstract excerpt

Newborn combined lipase-deficient (cld) mice have severe hypertriglyceridemia associated with a marked decrease of lipoprotein lipase (LPL) and hepatic lipase (HL) activities. Since the cld mutation and lipase genes reside on separate chromosomes, combined lipase deficiency cannot result from defects occurring within the LPL or HL structural genes. To elucidate the biochemical basis of this trans-acting defect,...

Topics

Animals
Animals, Newborn
Brain
Complement Factor D
Heparin
Kidney
Kinetics
Lipase
Lipoprotein Lipase
Liver
Mice
Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes, Liver

Mutation

Myocardium

RNA, Messenger

Reference Values

Serine Endopeptidases

Source

Open in PubMed

Identifiers

PMID: 2211673

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2211673-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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