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Article

A Preferred Target DNA Structure for Retroviral Integrasein Vitro

1 Sept 1998

Abstract excerpt

The retroviral integrase protein catalyzes the insertion of linear viral DNA ends into the host cell DNA. Although integration in vivo is not site-specific, the detection of local and regional preferences within cellular DNA suggests that the integration reaction can be influenced by specific features of host DNA or chromatin. Here we describe highly preferred in vitro integration sites for avian sarcoma virus...

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Identifiers

PMID: 9727042
DOI: 10.1074/jbc.273.37.24190

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