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Article

Role of DNA end distortion in catalysis by avian sarcoma virus integrase.

The Journal of biological chemistry - 7 Sept 2001

Katz R A, DiCandeloro P, Kukolj G, Skalka A M

Abstract excerpt

Retroviral integrase (IN) recognizes linear viral DNA ends and introduces nicks adjacent to a highly conserved CA dinucleotide usually located two base pairs from the 3'-ends of viral DNA (the "processing" reaction). In a second step, the same IN active site catalyzes the insertion of these ends into host DNA (the "joining" reaction). Both DNA sequence and DNA structure contribute to specific recognition of viral...

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Identifiers

PMID: 11441016
DOI: 10.1074/jbc.M104632200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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