Article
Retrovirus DNA termini bound by integrase communicate in trans for full-site integration in vitro.
Virology - 5 Jul 1999
McCord M, Chiu R, Vora A C, Grandgenett D P
Abstract excerpt
Integration of linear retrovirus DNA involves the concerted insertion of the viral termini (full-site integration) into the host chromosome. We investigated the interactions that occur between long terminal repeat (LTR) termini bound by avian retrovirus integrase (IN) for full-site integration in vitro. Wild-type (wt) or mutant LTR donors that possess gain-of-function ("G") or loss-of-function ("L") for full-site...
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