Article
Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor.
The Journal of biological chemistry - 11 Sept 1998
Grasso L, Huang M, Sullivan C D, Messler C J, Kiser M B, Dragwa C R, Holroyd K J, Renauld J C, Levitt R C, Nicolaides N C
Abstract excerpt
Genetic studies on mouse models of asthma have identified interleukin-9 (IL9) as a determining factor in controlling bronchial hyperresponsiveness, a hallmark of the disease. Recently, the human IL9 receptor (hIL9R) gene locus has also been implicated in determining susceptibility to bronchial hy...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- COS Cells
- Cloning, Molecular
- Codon
- Flow Cytometry
- Genetic Variation
- Humans
- Interleukin-9
- Lymphocyte Activation
- Lymphocytes
- Mice
- Polymerase Chain Reaction